Valerie D. Callender, MD is from Callender Skin and Laser Center, Mitchellville, Maryland. Norman Preston, PhD; Cris Osborn, PhD; Lori Johnson, PhD; and Ronald W. Gottschalk, MD are from Galderma Laboratories, LP, Fort Worth, Texas

Disclosure: Dr. Callender is a clinical researcher and consultant for Galderma. Drs. Preston, Osborn, Johnson, and Gottschalk are employed by Galderma. Read the rest of this article »

Jason J. Emer, MD; Amylynne Frankel, MD; Joshua A. Zeichner, MD
Mount Sinai School of Medicine, Department of Dermatology, New York, New York

Disclosure: Drs. Emer and Frankel report no relevant conflicts of interest. Dr. Zeichner is an investigator for Centocor.

Abstract
Psoriasis is a chronic, systemic, inflammatory skin condition that manifests predominantly as well-demarcated, erythematous, scaly plaques on the elbows, knees, and scalp. While mild cases (minimal body surface) often respond to various topical treatments and light therapy, patients with extensive disease (larger body surface and possibly joint involvement) may require systemic medications for remission. The development of biological agents provides dermatologists valuable ways to help treat psoriatic disease quite efficiently, but literature regarding the monitoring of patients on biological treatments is sparse. Clinical practice varies widely since there is modest strong evidence to recommend or refute most tests currently recommended by the United States Food and Drug Administration. The purpose of this article is to present a practical approach to monitoring patients on biological therapy based on the most up-to-date literature.  (J Clin Aesthetic Dermatol. 2010;3(8):20–26.) Read the rest of this article »

Richard N. Sherman, MD
Skin Institute of New Orleans, New Orleans, Louisiana; Clinical Associate Professor,
Department of Dermatology, Tulane University, New Orleans, Louisiana

Disclosure: Dr. Sherman is a speaker, master trainer, and advisory board member for Sanofi-Aventis U.S. LLC. Editorial support for this article was provided by the editorial staff at Embryon. This article was funded by Dermik Laboratories, a business of Sanofi-Aventis U.S. The author gratefully acknowledges Marci Mikesell, PhD, who assisted in the preparation of this article based on author-provided comments. The author was fully responsible for the content, editorial decisions, and opinions expressed in the current article. The author received no honoraria or other form of financial support related to the development of this manuscript. Read the rest of this article »

Steven M. Dean, DO, FACP, RPVI; Matthew Zirwas, MD
The Ohio State University, Columbus, Ohio

Disclosure: Drs. Dean and Zirwas report no relevant conflicts of interest.

Abstract
Pyoderma gangrenosum is a painful, noninfectious, ulcerative, cutaneous disorder that most commonly affects the lower extremities. The diagnosis is made by recognizing the characteristic clinical manifestations in the setting of a causative systemic disease and excluding other causes of similar-appearing ulcerations. Pyoderma gangrenosum often evolves in the setting of systemic illnesses, such as inflammatory bowel disease, rheumatological disorders, and hematological conditions. However, several medications have rarely been linked to pyoderma gangrenosum. The authors report the second case of sunitinib-associated pyoderma gangrenosum in a 61-year-old patient with recurrent renal cell carcinoma.  (J Clin Aesthetic Dermatol. 2010;3(8):34–35.) Read the rest of this article »

Michael H. Gold, MD

Dr. Gold is the founder and medical director of Gold Skin Care Center, Advanced Aesthetics Medical Spa, The Laser and Rejuvenation Center, and Tennessee Clinical Research Center located in Nashville, Tennessee. He is also Clinical Assistant Professor at Vanderbilt University School of Medicine and School of Nursing in Nashville, Tennessee; Visiting Professor of Dermatology, Huashan Hospital, Fudan University, Shanghai, China; and Visiting Professor of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China. Dr. Gold has performed clinical research for Allergan, Medicis, Mentor, and Suneva Medical. Read the rest of this article »

James Q. Del Rosso, DO, FAOCD; Grace K. Kim, DO

Dr. Del Rosso is Dermatology Residency Director, Valley Hospital Medical Center, Las Vegas, Nevada. Dr. Kim is Dermatology Research Fellow, Mohave Skin & Cancer Clinics, Las Vegas, Nevada. Disclosure: Dr. Del Rosso is a consultant, speaker, and or researcher for Allergan, Coria, Galderma, Graceway, Intendis, Leo Pharma, Medicis, Onset Therapeutics, Ortho Dermatology, PharmaDerm, Quinnova, Ranbaxy, SkinMedica, Stiefel, Triax, Unilever, and Warner Chilcott. Dr. Kim reports no relevant conflicts of interest. Read the rest of this article »